Sirt1^tm1.1Auw
Targeted Allele Detail

Summary

• Symbol: Sirt1^tm1.1Auw
• Name: sirtuin 1; targeted mutation 1.1, Johan Auwerx
• MGI ID: MGI:5538566
• Synonyms: Sirt1^L2, Sirt1^tm1.1Aux
• Gene: Sirt1 Location: Chr10:63154784-63174814 bp, - strand Genetic Position: Chr10, 32.57 cM
• Alliance: Sirt1^tm1.1Auw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200083
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted into intron 4 and a second loxP site into intron 7. The neo cassette was removed through subsequent Flp-mediated recombination, leaving a conditional-ready allele with exons 5-7 floxed. (J:200083)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sirt1 Mutation: 83 strains or lines available

References

• Original: J:200083 Mouchiroud L, et al., The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell. 2013 Jul 18;154(2):430-41
• All: 6 reference(s)