Trim62^tm1Akil
Targeted Allele Detail

Summary

• Symbol: Trim62^tm1Akil
• Name: tripartite motif-containing 62; targeted mutation 1, Ann McNeill Killary
• MGI ID: MGI:5538538
• Synonyms: Dear1^tm1Aki
• Gene: Trim62 Location: Chr4:128777837-128805119 bp, + strand Genetic Position: Chr4, 62.38 cM
• Alliance: Trim62^tm1Akil page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:204336
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the 5' end of exon 1. Immunohistochemistry confirmed the absence of protein expression in the lungs. (J:204336)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trim62^tm1Akil

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim62 Mutation: 21 strains or lines available

References

• Original: J:204336 Chen N, et al., DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-beta-driven epithelial-mesenchymal transition. Cancer Discov. 2013 Oct;3(10):1172-89
• All: 2 reference(s)