Hltftm1.2Geno
Targeted Allele Detail
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Symbol: |
Hltftm1.2Geno |
Name: |
helicase-like transcription factor; targeted mutation 1.2, Genoway |
MGI ID: |
MGI:5532313 |
Gene: |
Hltf Location: Chr3:20111975-20172654 bp, + strand Genetic Position: Chr3, 6.15 cM
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Alliance: |
Hltftm1.2Geno page
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Widespread vacuolation in the anteriorcommissure, preoptic/ventral palladium, and motor cortex of Hltftm1.2Geno/Hltftm1.2Geno neonatal brains
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:203735
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 11. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 12. Flp-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exons 11 and 12. Western blot analysis confirmed the absence of protein expression in the heart, lung, liver, kidney and spleen.
(J:203735)
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Generation of the Hltftm1.2Geno allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hltf Mutation: |
47 strains or lines available
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Original: |
J:203735 Helmer RA, et al., Role of helicase-like transcription factor (hltf) in the G2/m transition and apoptosis in brain. PLoS One. 2013;8(6):e66799 |
All: |
6 reference(s) |
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