Ass1^tm1.2Ekoe
Targeted Allele Detail

Summary

• Symbol: Ass1^tm1.2Ekoe
• Name: argininosuccinate synthetase 1; targeted mutation 1.2, Eleonore Kohler
• MGI ID: MGI:5529836
• Gene: Ass1 Location: Chr2:31360282-31410682 bp, + strand Genetic Position: Chr2, 21.81 cM
• Alliance: Ass1^tm1.2Ekoe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203474
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 13. An additional loxP site was inserted downstream of exon 13. Flpe-mediated recombination removed the neomycin resistance cassette. Cre-mediated recombination removed exon 13. (J:203474)

Generation of the Ass1^tm1.1Ekoe and Ass1^tm1.2Ekoe alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ass1 Mutation: 56 strains or lines available

References

• Original: J:203474 Marion V, et al., Hepatic adaptation compensates inactivation of intestinal arginine biosynthesis in suckling mice. PLoS One. 2013;8(6):e67021
• All: 1 reference(s)