Clec4e^{tm1.1(Hbegf)Shoy}
Targeted Allele Detail

Summary

• Symbol: Clec4e^{tm1.1(Hbegf)Shoy}
• Name: C-type lectin domain family 4, member e; targeted mutation 1.1, Sho Yamasaki
• MGI ID: MGI:5528855
• Synonyms: Clec4e^gfp, dn
• Gene: Clec4e Location: Chr6:123258748-123266829 bp, - strand Genetic Position: Chr6, 58.35 cM, cytoband F3
• Alliance: Clec4e^{tm1.1(Hbegf)Shoy} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203159
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout, Reporter)
• Mutation: Insertion
• Clec4e^{tm1.1(Hbegf)Shoy} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Hbegf

• Mutation details: The targeting vector that inserted into exon 1 contained an EGFP, IRES, diphtheria toxin receptor, and floxed neomycin resistance cassette. Cre-mediated recombination removed the neomycin resistance cassette. Bone marrow-derived dendritic cells lack protein expression. (J:203159)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec4e Mutation: 24 strains or lines available

References

• Original: J:203159 Miyake Y, et al., C-type lectin MCL is an FcRgamma-coupled receptor that mediates the adjuvanticity of mycobacterial cord factor. Immunity. 2013 May 23;38(5):1050-62
• All: 1 reference(s)