Acot7^tm1.1Mwol
Targeted Allele Detail

Summary

• Symbol: Acot7^tm1.1Mwol
• Name: acyl-CoA thioesterase 7; targeted mutation 1.1, Michael J Wolfgang
• MGI ID: MGI:5528815
• Synonyms: Acot7^flox
• Gene: Acot7 Location: Chr4:152262591-152356312 bp, + strand Genetic Position: Chr4, 82.93 cM
• Alliance: Acot7^tm1.1Mwol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203753
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted usptream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. (J:203753)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acot7 Mutation: 50 strains or lines available

References

• Original: J:203753 Ellis JM, et al., Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity. Mol Cell Biol. 2013 May;33(9):1869-82
• All: 3 reference(s)