Tnfaip3^tm3.1Ama
Targeted Allele Detail

Summary

• Symbol: Tnfaip3^tm3.1Ama
• Name: tumor necrosis factor, alpha-induced protein 3; targeted mutation 3.1, Averil Ma
• MGI ID: MGI:5528684
• Synonyms: Tnfaip3^OTU
• Gene: Tnfaip3 Location: Chr10:18876658-18891158 bp, - strand Genetic Position: Chr10, 8.08 cM
• Alliance: Tnfaip3^tm3.1Ama page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203160
• Parent Cell Line: PRX-B6T (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 3. Exon 3 was replaced with one in which a nucleotide substitution(s) results(s) in the amino acid substitution of alanine for cysteine at position 103 (C103A). This mutation disrupts the deubiquitinating function of the OTU domain. Cre-mediated recombination removed the neomycin resistance cassette. (J:203160)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfaip3 Mutation: 44 strains or lines available

References

• Original: J:203160 Lu TT, et al., Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. Immunity. 2013 May 23;38(5):896-905
• All: 3 reference(s)