Bcl2l11^tm4Boul
Targeted Allele Detail

Summary

• Symbol: Bcl2l11^tm4Boul
• Name: BCL2 like 11; targeted mutation 4, Philippe Bouillet
• MGI ID: MGI:5527367
• Synonyms: Bim^deltaDEF2
• Gene: Bcl2l11 Location: Chr2:127967958-128004467 bp, + strand Genetic Position: Chr2, 62.23 cM, cytoband F3-G1
• Alliance: Bcl2l11^tm4Boul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203181
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions (TTCTCTTTT to GCTTCTGCT) within exon 3 result in the amino acid substitutions of alanine, serine and alanine for phenylalanine, serine and phenylalanine at positions 93, 94 and 95. These mutations in the Erk docking site (DEF2) abolishes Erk1/2 binding. This allele produces only an EL isoform lacking the phosphorylation sites associated with degradation of the protein. (J:203181)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl2l11 Mutation: 32 strains or lines available

References

• Original: J:203181 Clybouw C, et al., Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo. Cell Death Differ. 2012 Jun;19(6):1060-8
• All: 1 reference(s)