Cnr1^tm2Ltz
Targeted Allele Detail

Summary

• Symbol: Cnr1^tm2Ltz
• Name: cannabinoid receptor 1; targeted mutation 2, Beat Lutz
• MGI ID: MGI:5523992
• Synonyms: CB1^stop, Stop-CB1
• Gene: Cnr1 Location: Chr4:33924593-33948831 bp, + strand Genetic Position: Chr4, 16.28 cM
• Alliance: Cnr1^tm2Ltz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199647
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed STOP cassette was inserted upstream of the coding sequence that blocks expression. Western blot analysis confirmed the absence of protein expression. (J:199647)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cnr1 Mutation: 43 strains or lines available

References

• Original: J:199647 Ruehle S, et al., Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions. J Neurosci. 2013 Jun 19;33(25):10264-77
• All: 13 reference(s)