Robo4^tm1.1Xby
Targeted Allele Detail

Summary

• Symbol: Robo4^tm1.1Xby
• Name: roundabout guidance receptor 4; targeted mutation 1, Xiao-bing Yuan
• MGI ID: MGI:5523987
• Synonyms: floxed-robo4, Robo4^floxed
• Gene: Robo4 Location: Chr9:37313198-37325319 bp, + strand Genetic Position: Chr9, 20.76 cM
• Alliance: Robo4^tm1.1Xby page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202213
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Two loxP sites were inserted flanking exon 3, and a FRT-flanked neomycin cassette was inserted in intron 2. Flp recombinase mediated recombination removed neomycin cassette. (J:202213)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Robo4 Mutation: 87 strains or lines available

References

• Original: J:202213 Zheng W, et al., Robo4 regulates the radial migration of newborn neurons in developing neocortex. Cereb Cortex. 2012 Nov;22(11):2587-601
• All: 3 reference(s)