Tg(Camk2a-HBEGF)BNKza
Transgene Detail

Summary

• Symbol: Tg(Camk2a-HBEGF)BNKza
• Name: transgene insertion B, Kazu Nakazawa
• MGI ID: MGI:5523547
• Synonyms: DTR^loxP, fDTR, fDTR-line-B
• Transgene: Tg(Camk2a-HBEGF)BNKza Location: unknown
• Alliance: Tg(Camk2a-HBEGF)BNKza page

Transgene origin

• Strain of Origin: C57BL/6N

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Camk2a-HBEGF)BNKza expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: A targeting construct contained the Camk2a promoter, a loxp flanked alkaline phosphates-pA stop cassette and the sequence for the human homolog of heparin-binding epidermal growth factor-like growth factor (HBEGF) which functions as a diphtheria toxin receptor (DTR) in mice. Lines A and B were generated with line B exhibiting reduced expression compared with line A. Upon cre-mediated excision of the floxed AP stop cassette, the DTR is expressed making it possible to ablate specific cell populations. (J:197654)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:197654 Jinde S, et al., Hilar mossy cell degeneration causes transient dentate granule cell hyperexcitability and impaired pattern separation. Neuron. 2012 Dec 20;76(6):1189-200
• All: 1 reference(s)