Pappa^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Pappa^tm1Lex
• Name: pregnancy-associated plasma protein A; targeted mutation 1, Lexicon Genomics
• MGI ID: MGI:5523410
• Synonyms: fPAPP-A
• Gene: Pappa Location: Chr4:65042411-65275746 bp, + strand Genetic Position: Chr4, 34.14 cM
• Alliance: Pappa^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201775
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. (J:201775)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pappa Mutation: 71 strains or lines available

References

• Original: J:201775 Conover CA, et al., Inducible knock out of pregnancy-associated plasma protein-a gene expression in the adult mouse: effect on vascular injury response. Endocrinology. 2013 Aug;154(8):2734-8
• All: 4 reference(s)