Lmnb1^tm2Sgy
Targeted Allele Detail

Summary

• Symbol: Lmnb1^tm2Sgy
• Name: lamin B1; targeted mutation 2, Stephen G Young
• MGI ID: MGI:5517592
• Synonyms: Lmnb1^CS
• Gene: Lmnb1 Location: Chr18:56840885-56886496 bp, + strand Genetic Position: Chr18, 30.84 cM
• Alliance: Lmnb1^tm2Sgy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197315
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The TGT cysteine codon of the CaaX motif was changed to a TCT serine codon. In addition, a floxed neo resistance cassette was introduced 1.5 kb downstream of the point mutation. (J:197315)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmnb1 Mutation: 38 strains or lines available

References

• Original: J:197315 Jung HJ, et al., Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1923-32
• All: 1 reference(s)