Pomctm1e(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Pomctm1e(EUCOMM)Hmgu |
Name: |
pro-opiomelanocortin-alpha; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:5516646 |
Gene: |
Pomc Location: Chr12:4004951-4010642 bp, + strand Genetic Position: Chr12, 1.99 cM
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IMPC: |
Pomc gene page |
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Mutant Cell Lines: |
HEPD0915_5_A07, HEPD0915_5_A11, HEPD0915_5_C08, HEPD0915_5_E02, HEPD0915_5_E04, HEPD0915_5_E09, HEPD0915_5_E11, HEPD0915_5_F08, HEPD0915_5_F09, HEPD0915_5_F11, HEPD0915_5_G08, HEPD0915_5_G09, HEPD0915_5_G10 |
Germline Transmission: |
Unknown
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 4009427 of Chromosome 12 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:157065)
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Original: |
J:157065 Helmholtz Zentrum Muenchen GmbH, Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu). MGI Direct Data Submission. 2010-2015; |
All: |
1 reference(s) |
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