Myo1c^tm1.1Biat
Targeted Allele Detail

Summary

• Symbol: Myo1c^tm1.1Biat
• Name: myosin IC; targeted mutation 1.1, Biomodels Austria
• MGI ID: MGI:5515767
• Gene: Myo1c Location: Chr11:75541330-75564736 bp, + strand Genetic Position: Chr11, 45.92 cM, cytoband C-E1
• Alliance: Myo1c^tm1.1Biat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200573
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Modified isoform(s)) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon E-1. A floxed neomycin resistance cassette was inserted downstream of exon E-1. Cre-mediated recombination removed exon E-1 and the neomycin resistance cassette. Western blot analysis confirmed the absence of nuclear Myo1c protein expression. (J:200573)

Generation of the Myo1c^tm1.1Biat allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo1c Mutation: 86 strains or lines available

References

• Original: J:200573 Venit T, et al., Mouse nuclear myosin I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus. PLoS One. 2013;8(4):e61406
• All: 1 reference(s)