Pbrm1^MommeD27
Chemically induced Allele Detail

Summary

• Symbol: Pbrm1^MommeD27
• Name: polybromo 1; modifier of murine metastable epialleles, D27
• MGI ID: MGI:5515370
• Gene: Pbrm1 Location: Chr14:30741095-30843549 bp, + strand Genetic Position: Chr14, 19.09 cM, cytoband B
• Alliance: Pbrm1^MommeD27 page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: A A-to-G single point mutation in exon 17 is predicted to result in a Y733C amino acid substitution in the encoded protein. Reduced amounts of encoded protein were detected on Western blot of embryonic tissue, suggesting that this allele is hypomorphic. (J:201508)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pbrm1 Mutation: 91 strains or lines available

References

• Original: J:201508 Daxinger L, et al., An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Genome Biol. 2013 Sep 11;14(9):R96
• All: 1 reference(s)