Glra1^tm3.1Geh
Targeted Allele Detail

Summary

• Symbol: Glra1^tm3.1Geh
• Name: glycine receptor, alpha 1 subunit; targeted mutation 3.1, Gregg E Homanics
• MGI ID: MGI:5515312
• Gene: Glra1 Location: Chr11:55405065-55499024 bp, - strand Genetic Position: Chr11, 33.12 cM
• Alliance: Glra1^tm3.1Geh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228551
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting construct was used to introduce a conditional knock-in to an exon 9 modulatory site (loxP-exon 9-FRT-Neo-FRT-loxP). The KK385-386AA (lysine to alanine) mutation represents an AAGAAG to GCCGCC sequence modification. Flp-mediated recombination removed the neomycin resistance cassette. (J:228551)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Glra1 Mutation: 28 strains or lines available

References

• Original: J:228551 Aguayo LG, et al., Altered sedative effects of ethanol in mice with alpha1 glycine receptor subunits that are insensitive to Gbetagamma modulation. Neuropsychopharmacology. 2014 Oct;39(11):2538-48
• All: 4 reference(s)