Igs1^{tm10(CAG-Bgeo,-Fzd6)Nat}
Targeted Allele Detail

Summary

• Symbol: Igs1^{tm10(CAG-Bgeo,-Fzd6)Nat}
• Name: intergenic site 1; targeted mutation 10, Jeremy Nathans
• MGI ID: MGI:5510967
• Synonyms: Iis1^{tm10(CAG-Bgeo,-Fz6)Nat}, Ubb^{tm2(CAG-Fzd6)Nat}, Z/3HAFz6
• Gene: Igs1 Location: unknown Genetic Position: Chr11, Syntenic
• Alliance: Igs1^{tm10(CAG-Bgeo,-Fzd6)Nat} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217610
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, No functional change)
• Mutation: Insertion
• Igs1^{tm10(CAG-Bgeo,-Fzd6)Nat} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fzd6 (MGI:108474)

• Mutation details: The following elements were inserted, in order into a region 2 kb 5' of the Ubb gene by targeted recombination: CMV enhancer/beta-actin promoter, loxP site, beta-geo, 3 stop transcription sites, loxP site, 3HA-Fzd6, rabbit beta-globin 3' UTR. The 3HA tag is inserted after the signal peptide and before the cysteine-rich domain of Fzd6. (J:217610)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igs1 Mutation: 10 strains or lines available

References

• Original: J:217610 Hua ZL, et al., Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance. Development. 2014 Oct;141(20):3944-54
• All: 1 reference(s)