Mgl2^{tm1.1(HBEGF/EGFP)Aiwsk}
Targeted Allele Detail

Summary

• Symbol: Mgl2^{tm1.1(HBEGF/EGFP)Aiwsk}
• Name: macrophage galactose N-acetyl-galactosamine specific lectin 2; targeted mutation 1.1, Akiko Iwasaki
• MGI ID: MGI:5510723
• Synonyms: CD301bGFP-DTR, Mgl2DTR, Mgl2^DTR-GFP
• Gene: Mgl2 Location: Chr11:70021155-70028376 bp, + strand Genetic Position: Chr11, 42.99 cM
• Alliance: Mgl2^{tm1.1(HBEGF/EGFP)Aiwsk} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201044
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout, Reporter)
• Mutation: Insertion
• Mgl2^{tm1.1(HBEGF/EGFP)Aiwsk} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: The targeting vector was designed to insert a human diphtheria toxin receptor (DTR)-enhanced green fluorescent protein (EGFP) fusion cassette, followed by a loxP-flanked neomycin (neo) resistance cassette, into exon 2. Cre-mediated recombination removed the neomycin resistance cassette. (J:201044)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mgl2 Mutation: 27 strains or lines available

References

• Original: J:201044 Kumamoto Y, et al., CD301b(+) dermal dendritic cells drive T helper 2 cell-mediated immunity. Immunity. 2013 Oct 17;39(4):733-43
• All: 16 reference(s)