Casp3^tm2.1Flv
Targeted Allele Detail

Summary

• Symbol: Casp3^tm2.1Flv
• Name: caspase 3; targeted mutation 2.1, Richard Flavell
• MGI ID: MGI:5510526
• Synonyms: Caspase-3^flox
• Gene: Casp3 Location: Chr8:47070326-47092724 bp, + strand Genetic Position: Chr8, 26.39 cM
• Alliance: Casp3^tm2.1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200588
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 2. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:219206)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp3 Mutation: 32 strains or lines available

References

• Original: J:200588 Ye J, et al., A pathway involving HDAC5, cFLIP and caspases regulates expression of the splicing regulator polypyrimidine tract binding protein in the heart. J Cell Sci. 2013 Apr 1;126(Pt 7):1682-91
• All: 5 reference(s)