Gt(ROSA)26Sor^{tm1(CAG-CXADR*)Mass}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-CXADR*)Mass}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Marc Schmidt-Supprian
• MGI ID: MGI:5509139
• Synonyms: CAG-CAR^stop-fl, R26/CAG-CARdelta1^StopF
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-CXADR*)Mass} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196136
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-CXADR*)Mass} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CXADR (1525)

  Cxadr

  (MGI:1201679)

  Truncated (amino acids 1-262)

• Mutation details: A cDNA encoding a truncated form of the human coxsackie adenovirus receptor (amino acids 1-262) under the control of a CAG promoter with a floxed neo-STOP cassette between. (J:196136)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:196136 Vogel KU, et al., Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation. Immunity. 2013 Apr 18;38(4):655-68
• All: 8 reference(s)