Ezr^tm1Sats
Targeted Allele Detail

Summary

• Symbol: Ezr^tm1Sats
• Name: ezrin; targeted mutation 1, Sachiko Tsukita
• MGI ID: MGI:5508539
• Synonyms: Ez^-, Vil2^kd
• Gene: Ezr Location: Chr17:7005530-7050179 bp, - strand Genetic Position: Chr17, 4.38 cM
• Alliance: Ezr^tm1Sats page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200366
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct inserted into intron 2 a splice acceptor, IRES, lacZ, neomycin resistance cassette and polyadenylation sequence. Immunoblotting confirmed protein expression in small amounts in the stomach. (J:200366)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ezr Mutation: 84 strains or lines available

References

• Original: J:200366 Tamura A, et al., Achlorhydria by ezrin knockdown: defects in the formation/expansion of apical canaliculi in gastric parietal cells. J Cell Biol. 2005 Apr 11;169(1):21-8
• All: 6 reference(s)