Sarm1^tm1.1Diam
Targeted Allele Detail

Summary

• Symbol: Sarm1^tm1.1Diam
• Name: sterile alpha and HEAT/Armadillo motif containing 1; targeted mutation 1.1, Michael S Diamond
• MGI ID: MGI:5507721
• Gene: Sarm1 Location: Chr11:78363156-78388580 bp, - strand Genetic Position: Chr11, 46.74 cM
• Alliance: Sarm1^tm1.1Diam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:200140
• Parent Cell Line: SCC10 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with an MC1-neo resistance cassette. The selection cassette was subsequently excised from properly targeted mice by breeding to mice expressing a cre transgene. (J:200140)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sarm1 Mutation: 24 strains or lines available

References

• Original: J:200140 Szretter KJ, et al., The immune adaptor molecule SARM modulates tumor necrosis factor alpha production and microglia activation in the brainstem and restricts West Nile Virus pathogenesis. J Virol. 2009 Sep;83(18):9329-38
• All: 14 reference(s)