Ephb2^tm1.1Meg
Targeted Allele Detail

Summary

• Symbol: Ephb2^tm1.1Meg
• Name: Eph receptor B2; targeted mutation 1.1, Michael E Greenberg
• MGI ID: MGI:5505687
• Synonyms: EphB2^T699A
• Gene: Ephb2 Location: Chr4:136374850-136563299 bp, - strand Genetic Position: Chr4, 69.0 cM, cytoband D-E
• Alliance: Ephb2^tm1.1Meg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197489
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: A point mutation (A to G) in exon 11 results in the amino acid susbtitution of threonine with alanine at position 699 (p.T699A) in the encoded protein. This mutation creates a PP1 analog-sensitive protein. Cre-mediated recombination removed the loxP site flanked neomycin resistance gene cassette inserted into intron 11. (J:197489)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ephb2 Mutation: 69 strains or lines available

References

• Original: J:197489 Soskis MJ, et al., A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nat Neurosci. 2012 Dec;15(12):1645-54
• All: 2 reference(s)