Unc45b^m2Hfe
Chemically induced Allele Detail

Summary

• Symbol: Unc45b^m2Hfe
• Name: unc-45 myosin chaperone B; mtuation 2, Henry F Epstein
• MGI ID: MGI:5505494
• Synonyms: UNC-45b^Y735stop
• Gene: Unc45b Location: Chr11:82802112-82834284 bp, + strand Genetic Position: Chr11, 50.3 cM
• Alliance: Unc45b^m2Hfe page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T-to-A point mutation that results in the substitution tyrosine codon 735 with a stop codon (p.Y735*). Immunohistochemistry confirmed the absence of protein expression in the heart. (J:197773)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Unc45b Mutation: 50 strains or lines available

References

• Original: J:197773 Chen D, et al., Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac development. J Cell Sci. 2012 Aug 15;125(Pt 16):3893-903
• All: 2 reference(s)