Ifne^tm1.2Pjh
Targeted Allele Detail

Summary

• Symbol: Ifne^tm1.2Pjh
• Name: interferon epsilon; targeted mutation 1.2, Paul J Hertzog
• MGI ID: MGI:5503222
• Gene: Ifne Location: Chr4:88797775-88798438 bp, - strand Genetic Position: Chr4, 42.04 cM
• Alliance: Ifne^tm1.2Pjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197569
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the coding exon. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of the coding exon. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed the coding sequence. qRT-PCR confirmed the absence of transcript expression in uterus tissue. (J:197569)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifne Mutation: 18 strains or lines available

References

• Original: J:197569 Fung KY, et al., Interferon-epsilon protects the female reproductive tract from viral and bacterial infection. Science. 2013 Mar 1;339(6123):1088-92
• All: 4 reference(s)