Cul4btm1.1Yxg
Targeted Allele Detail
|
Symbol: |
Cul4btm1.1Yxg |
Name: |
cullin 4B; targeted mutation 1, Yaoqin Gong |
MGI ID: |
MGI:5500947 |
Synonyms: |
Cul4bnull |
Gene: |
Cul4b Location: ChrX:37622151-37665073 bp, - strand Genetic Position: ChrX, 22.81 cM, cytoband A2
|
Alliance: |
Cul4btm1.1Yxg page
|
|
Early developmental arrest in Cul4btm1.1Yxg/Y embryos
Show the 4 phenotype image(s) involving this allele.
|
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:199139
|
Parent Cell Line: |
RW-4 (ES Cell)
|
Strain of Origin: |
129X1/SvJ
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: A loxP site was inserted upstream of exon 3. An FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exons 3 through 5. Immunohistochemistry confirmed the absence of protein expression in embryos.
(J:199139)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Cul4b Mutation: |
37 strains or lines available
|
|
Original: |
J:199139 Jiang B, et al., Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development. PLoS One. 2012;7(5):e37070 |
All: |
4 reference(s) |
|