Rr695562^tm1.1Glh
Targeted Allele Detail

Summary

• Symbol: Rr695562^tm1.1Glh
• Name: regulatory region 695562; targeted mutation 1.1, David J Goldhamer
• MGI ID: MGI:5500170
• Synonyms: DRR^loxP, Myod1^tm2.1Glh
• Gene: Rr695562 Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Rr695562^tm1.1Glh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76260
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A 1.9-kb genomic fragment containing the 714-bp downstream regulatory region was replaced with a neomycin resistance gene cassette flanked by loxP sites. The neo selection cassette was subsequently removed by transient cre expression. Nothern blot analysis confirmed restored transcript expression levels. (J:76260)

Expression

In Mice Carrying this Mutation:

26 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr695562 Mutation: 0 strains or lines available

References

• Original: J:76260 Chen JC, et al., Essential and redundant functions of the MyoD distal regulatory region revealed by targeted mutagenesis. Dev Biol. 2002 May 1;245(1):213-23
• All: 1 reference(s)