Sirt2^tm1.2Auw
Targeted Allele Detail

Summary

• Symbol: Sirt2^tm1.2Auw
• Name: sirtuin 2; targeted mutation 1.2, Johan Auwerx
• MGI ID: MGI:5499209
• Synonyms: Sirt2^tm1.2Jmi
• Gene: Sirt2 Location: Chr7:28466192-28488086 bp, + strand Genetic Position: Chr7, 16.92 cM, cytoband B1-2
• Alliance: Sirt2^tm1.2Auw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neo cassette and left exons 5 through 7 floxed. Cre-mediated recombination removed exons 5 through 7. Western blot analysis confirmed the absence of protein expression in the spinal cord, brain and sciatic nerve. (J:177468, J:194977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt2 Mutation: 29 strains or lines available

References

• Original: J:194977 Taes I, et al., Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS. Hum Mol Genet. 2013 May 1;22(9):1783-90
• All: 5 reference(s)