Dock1^tm1Ysfk
Targeted Allele Detail

Summary

• Symbol: Dock1^tm1Ysfk
• Name: dedicator of cytokinesis 1; targeted mutation 1, Yoshinori Fukui
• MGI ID: MGI:5499195
• Synonyms: DOCK1^flox
• Gene: Dock1 Location: Chr7:134272416-134775376 bp, + strand Genetic Position: Chr7, 79.14 cM
• Alliance: Dock1^tm1Ysfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178190
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: One loxP site was inserted upstream of exon 2 (containing the SH3 domain) and a floxed neomycin resistance cassette was inserted downstream. (J:178190)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock1 Mutation: 130 strains or lines available

References

• Original: J:178190 Sanematsu F, et al., DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4. Circ Res. 2010 Oct 29;107(9):1102-5
• All: 2 reference(s)