Ttbk2^bby
Chemically induced Allele Detail

Summary

• Symbol: Ttbk2^bby
• Name: tau tubulin kinase 2; bartleby
• MGI ID: MGI:5496675
• Gene: Ttbk2 Location: Chr2:120563297-120681085 bp, - strand Genetic Position: Chr2, 60.37 cM, cytoband F1
• Alliance: Ttbk2^bby page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A-to-T mutation within the coding region that changes lysine codon 143 to a stop codon (p.K143*). The affected residue is located in the kinase domain of the encoded peptide. (J:98216, J:197579)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttbk2 Mutation: 63 strains or lines available

References

• Original: J:197579 Goetz SC, et al., The spinocerebellar ataxia-associated gene Tau tubulin kinase 2 controls the initiation of ciliogenesis. Cell. 2012 Nov 9;151(4):847-58
• All: 3 reference(s)