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Flgtm1Amag
Targeted Allele Detail
Summary
Symbol: Flgtm1Amag
Name: filaggrin; targeted mutation 1, Masayuki Amagai
MGI ID: MGI:5496587
Gene: Flg  Location: Chr3:93180853-93200996 bp, + strand  Genetic Position: Chr3, 40.16 cM
Alliance: Flgtm1Amag page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198332
Parent Cell Line:  iTL BA1 (ES Cell)
Strain of Origin:  (C57BL/6NTac x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced part of exon 2 and 3. Westen blot analysis confirmed the absence of protein expression. (J:198332)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Flg Mutation:  42 strains or lines available
References
Original:  J:198332 Kawasaki H, et al., Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice. J Allergy Clin Immunol. 2012 Jun;129(6):1538-46.e6
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory