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Homer1tm1Kino
Targeted Allele Detail
Summary
Symbol: Homer1tm1Kino
Name: homer scaffolding protein 1; targeted mutation 1, Kaoru Inokuchi
MGI ID: MGI:5496433
Synonyms: Vesl-1L-
Gene: Homer1  Location: Chr13:93436143-93541637 bp, + strand  Genetic Position: Chr13, 47.83 cM
Alliance: Homer1tm1Kino page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:198336
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe portion coding the C-terminal 11 amino acids was replaced by a cDNA encoding the long form-specific C-terminal amino acid (exons 7 through 11) followed by a polyadenylation sequence and a neomycin resistance cassette. Northern blot analysis confirmed transcript expression of the long isoform and not the short isoform. (J:198336)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Homer1 Mutation:  24 strains or lines available
References
Original:  J:198336 Inoue N, et al., Requirement of the immediate early gene vesl-1S/homer-1a for fear memory formation. Mol Brain. 2009;2:7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
09/24/2024
MGI 6.24
The Jackson Laboratory