Pstpip1^tm1.1Dtg
Targeted Allele Detail

Summary

• Symbol: Pstpip1^tm1.1Dtg
• Name: proline-serine-threonine phosphatase-interacting protein 1; targeted mutation 1.1, Douglas T Golenbock
• MGI ID: MGI:5496137
• Synonyms: Pstpip1 del
• Gene: Pstpip1 Location: Chr9:55997246-56036172 bp, + strand Genetic Position: Chr9, 30.13 cM, cytoband C
• Alliance: Pstpip1^tm1.1Dtg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196002
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 4 through 11. Western blot analysis confirmed the absence of protein expression in the thymus, spleen and bone marrow. (J:196002)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pstpip1 Mutation: 14 strains or lines available

References

• Original: J:196002 Wang D, et al., Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins. J Biol Chem. 2013 Feb 15;288(7):4594-601
• All: 1 reference(s)