Fto^tm1.2Rdc
Targeted Allele Detail

Summary

• Symbol: Fto^tm1.2Rdc
• Name: FTO alpha-ketoglutarate dependent dioxygenase; targeted mutation 1.2, Roger Cox
• MGI ID: MGI:5494490
• Gene: Fto Location: Chr8:92040153-92395067 bp, + strand Genetic Position: Chr8, 44.34 cM
• Alliance: Fto^tm1.2Rdc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194922
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination removed exon 3 and the neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in adult brain, adult liver and E17.5 body. (J:194922)

Schematic of the generation of Fto^tm1.1Rdc and Fto^tm1.2Rdc alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fto Mutation: 71 strains or lines available

References

• Original: J:194922 McMurray F, et al., Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genet. 2013 Jan;9(1):e1003166
• All: 4 reference(s)