Prdm1^tm3.1Liz
Targeted Allele Detail

Summary

• Symbol: Prdm1^tm3.1Liz
• Name: PR domain containing 1, with ZNF domain; targeted mutation 3.1, Elizabeth K Bikoff
• MGI ID: MGI:5491215
• Synonyms: Prdm1 deltaex7
• Gene: Prdm1 Location: Chr10:44313173-44404497 bp, - strand Genetic Position: Chr10, 23.24 cM
• Alliance: Prdm1^tm3.1Liz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196531
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 7. A floxed neo cassette was inserted downstream of exon 7. Cre-mediated recombination removed exon 7 and the neo cassette. Western blot analysis confirmed only expression of the short isoform. (J:196531)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Prdm1 Mutation: 64 strains or lines available

References

• Original: J:196531 Morgan MA, et al., Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions. Mol Cell Biol. 2012 Sep;32(17):3403-13
• All: 1 reference(s)