Dp(5Gtf2i-Gtf2ird1)1Lro
Targeted Allele Detail

Summary

• Symbol: Dp(5Gtf2i-Gtf2ird1)1Lro
• Name: duplication, Chr 5, L Osborne 1
• MGI ID: MGI:5490970
• Synonyms: Dp(5)1Lro, Gtf2i^Dup
• Gene: Dp(5Gtf2i-Gtf2ird1)1Lro Location: unknown Genetic Position: Chr5, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196809
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Duplication, Insertion
• Dp(5Gtf2i-Gtf2ird1)1Lro involves 2 genes/genome features (Gtf2i, Gtf2ird1) View all
• Mutation details: Cre-mediated recombination between loxP sites in intron 4 of Gtf2ird1^{Gt(XS0608)Wtsi} and downstream of exon 34 of Gtf2i^tm1Lro produced a duplication of the intervening sequence. Western blot analysis confirmed increased expression of Gtf2i but not Gtf2ird1 in the brain. (J:196809, J:222543)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dp(5Gtf2i-Gtf2ird1)1Lro Mutation: 1 strain or line available

Notes

Gtf2ird1^{Gt(XS0608)Wtsi} was generated in the E14.1TGa.4 ES cell line, derived from 129P2/OlaHsd, and Gtf2i^tm1Lro was made in the R1 ES cell line, derived from (129X1/SvJ x 129S1/Sv)F1-Kitl⁺.

References

• Original: J:196809 Mervis CB, et al., Duplication of GTF2I results in separation anxiety in mice and humans. Am J Hum Genet. 2012 Jun 8;90(6):1064-70
• All: 5 reference(s)