Ube2c^{tm1.1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Ube2c^{tm1.1(KOMP)Wtsi}
• Name: ubiquitin-conjugating enzyme E2C; targeted mutation 1.1, Wellcome Trust Sanger Institute
• MGI ID: MGI:5490487
• Gene: Ube2c Location: Chr2:164611849-164614822 bp, + strand Genetic Position: Chr2, 85.27 cM
• Alliance: Ube2c^{tm1.1(KOMP)Wtsi} page
• IMPC: Ube2c gene page

Mutation origin

• Mutant Cell Line: EPD0411_3_B02
• Germline Transmission: Earliest citation of germline transmission: J:188991
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 1935 starting at position 164612282 and ending at position 164614217 of Chromosome 2 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site was followed by a neomycin selection cassette under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Expression of cre recombinase excised the neomycin selection cassette. (J:148605, J:173534, J:188991)

Expression

In Mice Carrying this Mutation:

13 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ube2c Mutation: 25 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 7 reference(s)