Usp3^tm1.2Nki
Targeted Allele Detail

Summary

• Symbol: Usp3^tm1.2Nki
• Name: ubiquitin specific peptidase 3; targeted mutation 1.2, The Netherlands Cancer Institute
• MGI ID: MGI:5490049
• Gene: Usp3 Location: Chr9:66421919-66500424 bp, - strand Genetic Position: Chr9, 35.96 cM
• Alliance: Usp3^tm1.2Nki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218723
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 were floxed and an FRT-flanked puro cassette was inserted. Flp-mediated recombination removed the puro cassette. (J:218723)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp3 Mutation: 33 strains or lines available

References

• Original: J:218723 Lancini C, et al., Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells. J Exp Med. 2014 Aug 25;211(9):1759-77
• All: 1 reference(s)