Egr3^tm2.1Wgt
Targeted Allele Detail

Summary

• Symbol: Egr3^tm2.1Wgt
• Name: early growth response 3; targeted mutation 2.1, Warrren G Tourtellotte
• MGI ID: MGI:5489891
• Synonyms: Egr3^f
• Gene: Egr3 Location: Chr14:70314766-70320062 bp, + strand Genetic Position: Chr14, 36.2 cM, cytoband D1
• Alliance: Egr3^tm2.1Wgt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196371
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector inserted a forward-oriented loxP site into the intron of Egr3 and a PGK-neo selection marker flanked by forward-oriented Frt sites and second forward-oriented loxP site (3' to the neo) into exon 2 immediately downstream of the TGA translation stop codon. The neo marker was excised by mating mice to CAG-FLPe mice. (J:196371)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egr3 Mutation: 15 strains or lines available

References

• Original: J:196371 Quach DH, et al., A sympathetic neuron autonomous role for Egr3-mediated gene regulation in dendrite morphogenesis and target tissue innervation. J Neurosci. 2013 Mar 6;33(10):4570-83
• All: 2 reference(s)