Clip3^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Clip3^tm1.1Ics
• Name: CAP-GLY domain containing linker protein 3; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5489756
• Gene: Clip3 Location: Chr7:29991153-30007792 bp, + strand Genetic Position: Chr7, 17.37 cM, cytoband A3
• Alliance: Clip3^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194894
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1 and a second loxP site and an FRT site flanked neomycin resistance gene cassette were inserted into intron 5. The neo cassette was removed through subsequent Flp-mediated recombination and Cre-mediated recombination deleted exons 2-5. In homozygous mice, in situ hybridization and western blot analysis confirms the absence of protein expression in brain sections and spinal cord and cortex lysates, respectively. (J:194894)

Expression

In Mice Carrying this Mutation:	80 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clip3 Mutation: 15 strains or lines available

References

• Original: J:194894 Couesnon A, et al., CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. Development. 2013 Apr;140(7):1583-93
• All: 1 reference(s)