Aqp11^tm1.1Nlsn
Targeted Allele Detail

Summary

• Symbol: Aqp11^tm1.1Nlsn
• Name: aquaporin 11; targeted mutation 1.1, Soren Nielsenk
• MGI ID: MGI:5485013
• Synonyms: Aqp11^flx, Aqp11^tm1.1Aroj
• Gene: Aqp11 Location: Chr7:97375586-97387454 bp, - strand Genetic Position: Chr7, 53.57 cM
• Alliance: Aqp11^tm1.1Nlsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194939
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exons 2 and 3 floxed. (J:194939)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aqp11 Mutation: 16 strains or lines available

References

• Original: J:194939 Rojek A, et al., Liver-specific Aquaporin 11 knockout mice show rapid vacuolization of the rough endoplasmic reticulum in periportal hepatocytes after amino acid feeding. Am J Physiol Gastrointest Liver Physiol. 2013 Mar 1;304(5):G501-15
• All: 2 reference(s)