Tg(TNS4-cre)1Shlo
Transgene Detail

Summary

• Symbol: Tg(TNS4-cre)1Shlo
• Name: transgene insertion 1, Su Hao Lo
• MGI ID: MGI:5484658
• Synonyms: pCTEN-Cre
• Transgene: Tg(TNS4-cre)1Shlo Location: unknown
• Alliance: Tg(TNS4-cre)1Shlo page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(TNS4-cre)1Shlo expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  TNS4 (84951)

  Tns4	(MGI:2144377)

• Mutation details: The final transgenic construct contained a 327-bp fragment from -290 to +37, of the human TNS4 (tensin 4; CTEN) promoter, a synthetic intron sequence, cre recombinase cDNA with a nuclear localization signal, and an SV40 polyadenylation signal. The construct was microinjected into (C57BL/6 x CBA)F1 zygotes. No founder information or line numbers are available. Crosses with reporter mice show strong cre activity in the brain and prostate, occasional staining in islets in the pancreas, bronchiole epithelium of the lung and in some tubules of the testis. No activity is observed in the kidney, small intestine, thymus, heart, tongue, liver, spleen or mammary gland. (J:195302)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	TNS4 (human) Summary of all recombinase alleles driven by TNS4. Comparative matrix view of recombinase activities Alliance human TNS4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:195302 Chen NT, et al., Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene. Gene. 2013 May 15;520(2):90-7
• All: 1 reference(s)