Plp1^tm1.1Blyg
Targeted Allele Detail

Summary

• Symbol: Plp1^tm1.1Blyg
• Name: proteolipid protein (myelin) 1; targeted mutation 1.1, Baoli Yang
• MGI ID: MGI:5476996
• Synonyms: Plp1^deltaASE
• Gene: Plp1 Location: ChrX:135723420-135740482 bp, + strand Genetic Position: ChrX, 59.1 cM, cytoband F1-F2
• Alliance: Plp1^tm1.1Blyg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193537
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced the antisilencer/enhancer (ASE) element from intron 1. Cre-mediated recombination removed the neo cassette. Western blot analysis confirmed normal protein expression at P15 to P35. (J:193537)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plp1 Mutation: 19 strains or lines available

References

• Original: J:193537 Pereira GB, et al., Targeted deletion of the antisilencer/enhancer (ASE) element from intron 1 of the myelin proteolipid protein gene (Plp1) in mouse reveals that the element is dispensable for Plp1 expression in brain during development and remyelination. J Neurochem. 2013 Feb;124(4):454-65
• All: 1 reference(s)