Tg(Prnp-PRNP)110Jmto
Transgene Detail

Summary

• Symbol: Tg(Prnp-PRNP)110Jmto
• Name: transgene insertion 110, Juan Maria Torres
• MGI ID: MGI:5476799
• Synonyms: bo6ORTg, bo6ORTg110, BoPrP-Tg110, boTg110, Tg(moPrpn BoPrP)110Jmto
• Transgene: Tg(Prnp-PRNP)110Jmto Location: unknown
• Alliance: Tg(Prnp-PRNP)110Jmto page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1 x 129P2/OlaHsd-Prnp^tm2Edin

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-PRNP)110Jmto expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  cattle	PRNP (281427)

• Mutation details: The open reading frame of the bovine prion protein gene was inserted into an expression vector containing the mouse prion protein promoter, exon 1, intron 1, exon 2 and 3' untranslated region. Bovine prion protein expression in brains of homozygous transgenic mice of this line, as determined by western blot analysis, is 8-fold that observed in cow brain homogenate; none is detected in spleen, heart, skeletal muscle, testis or kidney of transgenic mice. (J:119197)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:119197 Castilla J, et al., Early detection of PrPres in BSE-infected bovine PrP transgenic mice. Arch Virol. 2003 Apr;148(4):677-91
• All: 8 reference(s)