Pomc^tm2.1Low
Targeted Allele Detail

Summary

• Symbol: Pomc^tm2.1Low
• Name: pro-opiomelanocortin-alpha; targeted mutation 2.1, Malcolm J Low
• MGI ID: MGI:5473422
• Synonyms: arcPomc⁺, arcPomc^rcue
• Gene: Pomc Location: Chr12:4004951-4010642 bp, + strand Genetic Position: Chr12, 1.99 cM
• Alliance: Pomc^tm2.1Low page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194013
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

Allele Type: Targeted (Modified regulatory region) Mutation: Insertion Mutation details: A floxed neo cassette was inserted between the first upstream neuronal enhancer (nPE1) and the deleted second neuronal enhancer (nPE2). Cre-mediated recombination removed the neo cassette and restored expression in the hypothalamic arcuate nucleus (Arc). (J:194013)

Generation of the Pomc^tm2.1Low allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pomc Mutation: 19 strains or lines available

References

• Original: J:194013 Bumaschny VF, et al., Obesity-programmed mice are rescued by early genetic intervention. J Clin Invest. 2012 Nov 1;122(11):4203-12
• All: 1 reference(s)