Sox17^{tm2(EGFP/cre)Mgn}
Targeted Allele Detail

Summary

• Symbol: Sox17^{tm2(EGFP/cre)Mgn}
• Name: SRY (sex determining region Y)-box 17; targeted mutation 2, Mark A Magnuson
• MGI ID: MGI:5468103
• Synonyms: Sox17.Cre-GFP, Sox17^GFPCre
• Gene: Sox17 Location: Chr1:4561154-4567577 bp, - strand Genetic Position: Chr1, 1.65 cM
• Alliance: Sox17^{tm2(EGFP/cre)Mgn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:193165
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (RMCE-ready, Recombinase, Reporter)
• Mutations: Insertion, Intragenic deletion
• Sox17^{tm2(EGFP/cre)Mgn} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sox17 (MGI:107543)

• Mutation details: Recombinase-mediated cassette exchange was used to insert exon 3 and a Cre/EGFP (enhanced Green Fluorescent Protein) fusion gene into the loxed cassette allele (LCA) thereby replacing the coding sequence. (J:193165)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sox17 (mouse) Summary of all recombinase alleles driven by Sox17. Alliance mouse Sox17 gene page

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox17 Mutation: 28 strains or lines available

References

• Original: J:193165 Choi E, et al., Dual lineage-specific expression of Sox17 during mouse embryogenesis. Stem Cells. 2012 Oct;30(10):2297-308
• All: 7 reference(s)