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Targeted Allele Detail
Symbol: Cx3cr1tm2.1(cre/ERT2)Jung
Name: C-X3-C motif chemokine receptor 1; targeted mutation 2.1, Steffen Jung
MGI ID: MGI:5467985
Synonyms: Cx3cr1creER
Gene: Cx3cr1  Location: Chr9:119877749-119897362 bp, - strand  Genetic Position: Chr9, 71.37 cM
Alliance: Cx3cr1tm2.1(cre/ERT2)Jung page
Germline Transmission:  Earliest citation of germline transmission: J:193038
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
Cx3cr1tm2.1(cre/ERT2)Jung expression driven by 1 gene
Mutation detailsA cre/ERT2 cassette with a floxed neo gene was inserted by RedE/T recombineering into a BAC containing the Cx3cr1 locus, replacing the coding exon of Cx3cr1. Properly targeted ES cells were aggregated with 8-cell embryos to generate chimeras. Chimeras were backcrossed to C57BL/6 mice. Tne neo was excised by crossing the animals to a cre deleter strain (Tg(Pgk1-cre)1Lni). (J:193038)
 Tissue activity of this recombinase allele
Driver: Cx3cr1 (mouse)
Summary of all recombinase alleles driven by Cx3cr1.

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cx3cr1 Mutation:  45 strains or lines available
Original:  J:193038 Yona S, et al., Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis. Immunity. 2013 Jan 24;38(1):79-91
All:  196 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory