Ptprg^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Ptprg^tm1.1Lex
• Name: protein tyrosine phosphatase receptor type G; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:5464886
• Synonyms: RPTPgamma C1060S
• Gene: Ptprg Location: Chr14:10227722-10916220 bp, - strand Genetic Position: Chr14, 6.33 cM, cytoband A2
• Alliance: Ptprg^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191998
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae
• Project Collection: Lexicon

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Nucleotide substitutions Mutation details: Exon 21 was replaced with a modified exon 21 in which nucleotide substitutions result in the amino acid substitution of serine for cysteine at position 1060 (C1060S). Cre-mediated recombination removed the floxed neo cassette inserted along with the modified exon 21. (J:191998)

Generation of the Ptprg^tm1.1Lex allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprg Mutation: 113 strains or lines available

References

• Original: J:191998 Zhang W, et al., Characterization of PTPRG in knockdown and phosphatase-inactive mutant mice and substrate trapping analysis of PTPRG in mammalian cells. PLoS One. 2012;7(9):e45500
• All: 1 reference(s)