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Transgene Detail
Symbol: Tg(Pbsn-cre/Esr1*)14Abch
Name: transgene insertion 14, Andreas Birbach
MGI ID: MGI:5461708
Synonyms: ProbasinBAC-MerCreMer
Transgene: Tg(Pbsn-cre/Esr1*)14Abch  Location: unknown  
Alliance: Tg(Pbsn-cre/Esr1*)14Abch page
Strain of Origin:  C57BL/6NCrl
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
Tg(Pbsn-cre/Esr1*)14Abch expression driven by 1 gene
Mutation detailsA BAC (#RP23-456A6; containing the entire mouse probasin (Pbsn) gene) was modified to insert a MerCreMer sequence (a double fusion of the cre recombinase cDNA sequence flanked on each end with a mutated murine estrogen receptor (mer) ligand-binding domain, resulting in tamoxifen-inducible cre expression) driven by the Pbsn promoter/enhancer region. The construct was microinjected into fertilized C57BL/6NCrl oocytes. Founder line 14 was established by breeding the founder, carrying 8-11 copies of the transgene, to wild-type C57BL/6J mice. (J:154786)
 Tissue activity of this recombinase allele
Driver: Pbsn (mouse)
Summary of all recombinase alleles driven by Pbsn.

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Original:  J:154786 Birbach A, et al., A Probasin-MerCreMer BAC allows inducible recombination in the mouse prostate. Genesis. 2009 Nov;47(11):757-64
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
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